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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name lambda-Carrageenan Oligosaccharides, Fluorouracil
Phytochemical Name lambda-Carrageenan Oligosaccharides (PubChem CID: / )
Anticancer drug Name Fluorouracil (PubChem CID: 3385 )
Structure of
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Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 578
Ref_1
Pair Name lambda-Carrageenan Oligosaccharides, Fluorouracil
Disease Info [ICD-11: 2B72] Gastric cancer Investigative
Biological Phenomena Induction-->Immunomodulatory
Gene Regulation Down-regulation Phosphorylation AKT1 hsa207
Down-regulation Expression BCL2 hsa596
Up-regulation Cleavage CASP8 hsa841
Up-regulation Expression IFNG hsa3458
Up-regulation Expression PAWR hsa5074
Down-regulation Expression RELA hsa5970
Up-regulation Expression TNF hsa7124
In Vitro Model BGC-823 Human papillomavirus-related cervical adenocarcinoma Homo sapiens (Human) CVCL_3360
THP-1 Childhood acute monocytic leukemia Homo sapiens (Human) CVCL_0006
In Vivo Model To generate the xenograft animal models, about 2×10⁷ BGC-823 cells in 100 μL PBS were subcutaneously injected into the left front axilla of BALB/c mice.
Result These findings suggested that λ-COS could be used as an immune-modulating agent for chemotherapy.
03. Reference
No. Title Href
1 The Antitumor Potential of λ-Carrageenan Oligosaccharides on Gastric Carcinoma by Immunomodulation. Nutrients. 2023 Apr 24;15(9):2044. doi: 10.3390/nu15092044. Click
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