
| Pair Name | lambda-Carrageenan Oligosaccharides, Fluorouracil | ||
| Phytochemical Name | lambda-Carrageenan Oligosaccharides (PubChem CID: / ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
Download
2D
MOL
3D
MOL
|
||
| Structure of Anticancer Drug |
Download
2D
MOL
3D
MOL
|
||
| Pair Name | lambda-Carrageenan Oligosaccharides, Fluorouracil | |||
| Disease Info | [ICD-11: 2B72.Z] | Gastric cancer | Investigative | |
| Biological Phenomena | Induction-->Immunomodulatory | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Cleavage | CASP8 | hsa841 | |
| Up-regulation | Expression | PAWR | hsa5074 | |
| Down-regulation | Expression | RELA | hsa5970 | |
| Up-regulation | Expression | TNF | hsa7124 | |
| Up-regulation | Expression | IFNG | hsa3458 | |
| In Vitro Model | BGC-823 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_3360 |
| THP-1 | Childhood acute monocytic leukemia | Homo sapiens (Human) | CVCL_0006 | |
| In Vivo Model | To generate the xenograft animal models, about 2×10⁷ BGC-823 cells in 100 μL PBS were subcutaneously injected into the left front axilla of BALB/c mice. | |||
| Result | These findings suggested that λ-COS could be used as an immune-modulating agent for chemotherapy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | The Antitumor Potential of λ-Carrageenan Oligosaccharides on Gastric Carcinoma by Immunomodulation. Nutrients. 2023 Apr 24;15(9):2044. doi: 10.3390/nu15092044. | Click |